Pharmacogenomic Effect/ADR for Amlodipine (DBSNPE000151)

Identifier
DBSNPE000151
Drug
Amlodipine (DB00381)
Interacting Gene/Enzyme
Natriuretic peptides A
Gene Name
NPPA
UniProt ID
P01160
Defining Change(s)
AA allelers5065
Allele Name
Not Available
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of adverse cardiovascular outcomes with diuretics.
References
  1. Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK: Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension. JAMA. 2008 Jan 23;299(3):296-307. doi: 10.1001/jama.299.3.296. [PubMed:18212314]