Pharmacogenomic Effect/ADR for Infliximab (DBSNPE000152)

Identifier
DBSNPE000152
Drug
Infliximab (DB00065)
Interacting Gene/Enzyme
Low affinity immunoglobulin gamma Fc region receptor III-A
Gene Name
FCGR3A
UniProt ID
P08637
Defining Change(s)
CC Allele (homozygous)rs1801274
Allele Name
Not Available
Genotype(s)
(C;C)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased ACR20 response when using infliximab to treat rheumatoid arthritis.
References
  1. Canete JD, Suarez B, Hernandez MV, Sanmarti R, Rego I, Celis R, Moll C, Pinto JA, Blanco FJ, Lozano F: Influence of variants of Fc gamma receptors IIA and IIIA on the American College of Rheumatology and European League Against Rheumatism responses to anti-tumour necrosis factor alpha therapy in rheumatoid arthritis. Ann Rheum Dis. 2009 Oct;68(10):1547-52. doi: 10.1136/ard.2008.096982. Epub 2008 Oct 17. [PubMed:18930989]