Pharmacogenomic Effect/ADR for Amitriptyline (DBSNPE000166)

Identifier
DBSNPE000166
Drug
Amitriptyline (DB00321)
Interacting Gene/Enzyme
Multidrug resistance protein 1
Gene Name
ABCB1
UniProt ID
P08183
Defining Change(s)
T > Crs2032583
Allele Name
Not Available
Genotype(s)
(C;C) / (C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of adverse events with amitriptyline
References
  1. de Klerk OL, Nolte IM, Bet PM, Bosker FJ, Snieder H, den Boer JA, Bruggeman R, Hoogendijk WJ, Penninx BW: ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder. Pharmacogenomics J. 2013 Aug;13(4):349-53. doi: 10.1038/tpj.2012.16. Epub 2012 May 29. [PubMed:22641028]