Pharmacogenomic Effect/ADR for Naltrexone (DBSNPE000169)

Identifier
DBSNPE000169
Drug
Naltrexone (DB00704)
Interacting Gene/Enzyme
Mu-type opioid receptor
Gene Name
OPRM1
UniProt ID
P35372
Defining Change(s)
A > Grs1799971
Allele Name
Not Available
Genotype(s)
(A;G) / (G;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have an increased number of abstinent days when using naltrexone to treat alcohol addiction.
References
  1. Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, Goldman D: An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry. 2008 Feb;65(2):135-44. doi: 10.1001/archpsyc.65.2.135. [PubMed:18250251]