Pharmacogenomic Effect/ADR for Donepezil (DBSNPE000193)

Identifier
DBSNPE000193
Drug
Donepezil (DB00843)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
C > Grs1080985
Allele Name
CYP2D6*2A
Genotype(s)
(C;G) / (G;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype are have a decreased likelihood of responding to donepezil when treating Alzheimer's disease.
References
  1. Albani D, Martinelli Boneschi F, Biella G, Giacalone G, Lupoli S, Clerici F, Benussi L, Ghidoni R, Galimberti D, Squitti R, Mariani S, Confaloni A, Bruno G, Mariani C, Scarpini E, Binetti G, Magnani G, Franceschi M, Forloni G: Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients. J Alzheimers Dis. 2012;30(4):745-9. doi: 10.3233/JAD-2012-112123. [PubMed:22465999]
  2. Pilotto A, Franceschi M, D'Onofrio G, Bizzarro A, Mangialasche F, Cascavilla L, Paris F, Matera MG, Pilotto A, Daniele A, Mecocci P, Masullo C, Dallapiccola B, Seripa D: Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. Neurology. 2009 Sep 8;73(10):761-7. doi: 10.1212/WNL.0b013e3181b6bbe3. [PubMed:19738170]