Pharmacogenomic Effect/ADR for Valproic acid (DBSNPE000273)

Identifier
DBSNPE000273
Drug
Valproic acid (DB00313)
Interacting Gene/Enzyme
DNA polymerase subunit gamma-1
Gene Name
POLG
UniProt ID
P54098
Defining Change(s)
G > Crs113994097
Allele Name
W748S
Genotype(s)
(C;C) / (C;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this polymorphism in POLG may indicate an increased risk of liver failure and death when treated with valproic acid.
References
Not Available