Pharmacogenomic Effect/ADR for Isoflurane (DBSNPE000352)

Identifier
DBSNPE000352, DBSNPE000353, DBSNPE000354, DBSNPE000355, DBSNPE000356, DBSNPE000357, DBSNPE000358, DBSNPE000359, DBSNPE000360, DBSNPE000361, DBSNPE000362, DBSNPE000363, DBSNPE000364, DBSNPE000365, DBSNPE000366, DBSNPE000367, DBSNPE000368, DBSNPE000369, DBSNPE000370, DBSNPE000371, DBSNPE000372, DBSNPE000373, DBSNPE000374, DBSNPE000375, DBSNPE000376, DBSNPE000377, DBSNPE000378, DBSNPE000379, DBSNPE000380, DBSNPE000381, DBSNPE000382, DBSNPE000383, DBSNPE000384, DBSNPE000385, DBSNPE000386
Drug
Isoflurane (DB00753)
Interacting Gene/Enzyme
Ryanodine receptor 1
Gene Name
RYR1
UniProt ID
P21817
Defining Change(s)
c.103T>Crs193922747
c.487C>Trs118192161
c.488G>Trs193922753
c.742G>Ars1801086
c.742G>Crs1801086
c.1021G>Ars121918592
c.1209C>Grs118192116
c.1565A>Crs118192162
c.1589G>ANot Available
c.1654C>Trs193922770
c.1840C>Trs118192172
c.1841G>Trs193922772
c.6487C>Trs118192175
c.6488G>Ars118192163
c.6502G>Ars118192176
c.6617C>Grs118192177
c.6617C>Trs118192177
c.7007G>ANot Available
c.7048G>Ars193922802
c.7124G>Crs193922807
c.7282G>Ars193922809
c.7300G>Ars121918593
c.7304G>Ars28933396
c.7360C>Trs193922816
c.7361G>Ars118192122
c.7372C>Trs28933397
c.7373G>Ars121918594
c.7522C>Trs118192178
c.7523G>ANot Available
c.14387A>Grs118192167
c.14477C>Trs121918595
c.14497C>TNot Available
c.14512C>Grs193922878
c.14582G>Ars63749869
c.14693T>Crs118192170
Allele Name
Not Available
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
Malignant hyperthermia vulnerability
Description
Malignant hyperthermia.
References
  1. ForaneĀ® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]