- Identifier
- DBSNPE001096
- Drug
- Dabrafenib (DB08912)
- Interacting Gene/Enzyme
- Glucose-6-phosphate 1-dehydrogenase
- Gene Name
- G6PD
- UniProt ID
- P11413
- Defining Change(s)
- Allele Name
- Georgia
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred
- Groups
- G6PD deficiency
- Description
- Increased risk of hemolytic anemia.
- References
- Welsh SJ, Corrie PG: Management of BRAF and MEK inhibitor toxicities in patients with metastatic melanoma. Ther Adv Med Oncol. 2015 Mar;7(2):122-36. doi: 10.1177/1758834014566428. [PubMed:25755684]
- Tafinlar® (dabrafenib) capsules[package insert]. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2016. [Link]