Pharmacogenomic Effect/ADR for Dabrafenib (DBSNPE001148)

Identifier
DBSNPE001148
Drug
Dabrafenib (DB08912)
Interacting Gene/Enzyme
Glucose-6-phosphate 1-dehydrogenase
Gene Name
G6PD
UniProt ID
P11413
Defining Change(s)
1052G->TNot Available
Allele Name
Partenope
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
G6PD deficiency
Description
Increased risk of hemolytic anemia.
References
  1. Welsh SJ, Corrie PG: Management of BRAF and MEK inhibitor toxicities in patients with metastatic melanoma. Ther Adv Med Oncol. 2015 Mar;7(2):122-36. doi: 10.1177/1758834014566428. [PubMed:25755684]
  2. TafinlarĀ® (dabrafenib) capsules[package insert]. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2016. [Link]