Pharmacogenomic Effect/ADR for Nitrofurantoin (DBSNPE002477)

Identifier
DBSNPE002477
Drug
Nitrofurantoin (DB00698)
Interacting Gene/Enzyme
Glucose-6-phosphate 1-dehydrogenase
Gene Name
G6PD
UniProt ID
P11413
Defining Change(s)
159G->CNot Available
Allele Name
Kozukata
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
G6PD deficiency
Description
Increased risk of hemolytic anemia.
References
  1. Gait JE: Hemolytic reactions to nitrofurantoin in patients with glucose-6-phosphate dehydrogenase deficiency: theory and practice. DICP. 1990 Dec;24(12):1210-3. [PubMed:2089833]
  2. Furadantin® (nitrofurantoin) Oral Suspension[package insert]. Florham Park, New Jersey: Shionogi Inc.; 2013. [Link]