Pharmacogenomic Effect/ADR for Pegloticase (DBSNPE002728)

Identifier
DBSNPE002728
Drug
Pegloticase (DB09208)
Interacting Gene/Enzyme
Glucose-6-phosphate 1-dehydrogenase
Gene Name
G6PD
UniProt ID
P11413
Defining Change(s)
835A->GNot Available
Allele Name
Haikou
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
G6PD deficiency
Description
Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References
  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]