Pharmacogenomic Effect/ADR for Gefitinib (DBSNPE004660)

Identifier
DBSNPE004660
Drug
Gefitinib (DB00317)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1584C>GNot Available
-1235A>GNot Available
-740C>TNot Available
-678G>ANot Available
CYP2D7 gene conversion in intron 1Not Available
1661G>CNot Available
2850C>TNot Available
3172A>CNot Available
4180G>CNot Available
Allele Name
CYP2D6*51
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer.
References
  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AstraZeneca Pharmaceuticals LP; 2015. [Link]