Pharmacogenomic Effect/ADR for Gefitinib (DBSNPE004662)

Identifier
DBSNPE004662
Drug
Gefitinib (DB00317)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
100C>TNot Available
310G>TNot Available
843T>GNot Available
887C>TNot Available
1039C>TNot Available
1661G>CNot Available
3384A>CNot Available
3582A>GNot Available
gene conversion to CYP2D7 in exon 9Not Available
4180G>CNot Available
Allele Name
CYP2D6*57
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer.
References
  1. Iressa® (gefitinib) tablets[package insert]. Wilmington, Delaware: AstraZeneca Pharmaceuticals LP; 2015. [Link]