Pharmacogenomic Effect/ADR for Pimozide (DBSNPE004753)

Identifier
DBSNPE004753
Drug
Pimozide (DB01100)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1584C>GNot Available
-1235A>GNot Available
-740C>TNot Available
-678G>ANot Available
CYP2D7 gene conversion in intron 1Not Available
1661G>CNot Available
2850C>TNot Available
3172A>CNot Available
4180G>CNot Available
Allele Name
CYP2D6*51
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirement.
References
  1. OrapĀ® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]