Pharmacogenomic Effect/ADR for Tetrabenazine (DBSNPE004821)

Identifier
DBSNPE004821
Drug
Tetrabenazine (DB04844)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1770G>ANot Available
-1584C>GNot Available
-1235A>GNot Available
-740C>TNot Available
-678G>ANot Available
CYP2D7 gene conversion in intron 1Not Available
310G>TNot Available
746C>GNot Available
843T>GNot Available
1661G>CNot Available
2850C>TNot Available
3384A>CNot Available
3584G>ANot Available
3790C>TNot Available
4042G>ANot Available
4180G>CNot Available
4481G>ANot Available
Allele Name
CYP2D6*31
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirement.
References
  1. Xenazine® (tetrabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]