Pharmacogenomic Effect/ADR for Tetrabenazine (DBSNPE004833)

Identifier
DBSNPE004833
Drug
Tetrabenazine (DB04844)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.Not Available
Allele Name
CYP2D6*68B
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirement.
References
  1. Xenazine® (tetrabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]