Pharmacogenomic Effect/ADR for Thioridazine (DBSNPE004859)

Identifier
DBSNPE004859
Drug
Thioridazine (DB00679)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1584C>GNot Available
-1235A>GNot Available
-740C>TNot Available
-678G>ANot Available
CYP2D7 gene conversion in intron 1Not Available
1661G>CNot Available
2850C>TNot Available
3172A>CNot Available
4180G>CNot Available
Allele Name
CYP2D6*51
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
Non-functional CYP2D6
Description
Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References
  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]