Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE005264)

Identifier
DBSNPE005264
Drug
Clomipramine (DB01242)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
124G>Ars5030862
Allele Name
CYP2D6*12
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References
  1. Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040]