Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE005393)

Identifier
DBSNPE005393
Drug
Clomipramine (DB01242)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
636G>Ars4986893
Allele Name
CYP2C19*3
Genotype(s)
Not Available
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C19
Description
The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of clomipramine.
References
  1. Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040]