Pharmacogenomic Effect/ADR for Codeine (DBSNPE005446)

Identifier
DBSNPE005446
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
100C>Trs1065852
-1426C>TNot Available
variable number of A’s in the region -1258 to -1237aNot Available
-1235A>GNot Available
-1000G>ANot Available
1039C>TNot Available
1661G>CNot Available
gene conversion to CYP2D7 in exon 9Not Available
4180G>CNot Available
Allele Name
CYP2D6*36
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References
  1. Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010]