Pharmacogenomic Effect/ADR for Codeine (DBSNPE005463)

Identifier
DBSNPE005463
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
2850C>Trs16947
4180G>Crs1135840
1661G>C duplicatedNot Available
Allele Name
CYP2D6*2XN
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
Ultra-rapid metabolizer CYP2D6
Description
Ultra-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.
References
  1. Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010]