Pharmacogenomic Effect/ADR for Acetylsalicylic acid (DBSNPE005528)

Identifier
DBSNPE005528
Drug
Acetylsalicylic acid (DB00945)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
1465C>Trs9332239
Allele Name
CYP2C9*12
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Decreased CYP2C9
Description
Poor drug metabolizer, lower dose requirements
References
  1. Blaisdell J, Jorge-Nebert LF, Coulter S, Ferguson SS, Lee SJ, Chanas B, Xi T, Mohrenweiser H, Ghanayem B, Goldstein JA: Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics. 2004 Aug;14(8):527-37. [PubMed:15284535]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]