Pharmacogenomic Effect/ADR for Acetylsalicylic acid (DBSNPE005536)

Identifier
DBSNPE005536
Drug
Acetylsalicylic acid (DB00945)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
395G>Ars200183364
Allele Name
CYP2C9*33
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Decreased CYP2C9
Description
Poor drug metabolizer, lower dose requirements
References
  1. Yin T, Maekawa K, Kamide K, Saito Y, Hanada H, Miyashita K, Kokubo Y, Akaiwa Y, Otsubo R, Nagatsuka K, Otsuki T, Horio T, Takiuchi S, Kawano Y, Minematsu K, Naritomi H, Tomoike H, Sawada J, Miyata T: Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan. Hypertens Res. 2008 Aug;31(8):1549-57. doi: 10.1291/hypres.31.1549. [PubMed:18971529]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]