Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE005563)

Identifier
DBSNPE005563
Drug
Clomipramine (DB01242)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
124G>Ars5030862
Allele Name
CYP2D6*12
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Marez D, Legrand M, Sabbagh N, Lo-Guidice JM, Boone P, Broly F: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine. Hum Genet. 1996 May;97(5):668-70. [PubMed:8655150]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]