Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE005568)

Identifier
DBSNPE005568
Drug
Clomipramine (DB01242)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
1973_1974insGrs72549354
Allele Name
CYP2D6*20
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Marez-Allorge D, Ellis SW, Lo Guidice JM, Tucker GT, Broly F: A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype. Pharmacogenetics. 1999 Jun;9(3):393-6. [PubMed:10471072]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]