Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE005570)

Identifier
DBSNPE005570
Drug
Clomipramine (DB01242)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1770G>ANot Available
-1584C>GNot Available
-1235A>GNot Available
-740C>TNot Available
-678G>ANot Available
CYP2D7 gene conversion in intron 1Not Available
310G>TNot Available
746C>GNot Available
843T>GNot Available
1661G>CNot Available
2850C>TNot Available
3384A>CNot Available
3584G>ANot Available
3790C>TNot Available
4042G>ANot Available
4180G>CNot Available
4481G>ANot Available
Allele Name
CYP2D6*31
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659]
  2. Allorge D, Breant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins. 2005 May 1;59(2):339-46. [PubMed:15726636]
  3. Gaedigk A, Isidoro-Garcia M, Pearce RE, Sanchez S, Garcia-Solaesa V, Lorenzo-Romo C, Gonzalez-Tejera G, Corey S: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep;66(9):859-64. doi: 10.1007/s00228-010-0831-4. Epub 2010 May 16. [PubMed:20473659]
  4. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]