Pharmacogenomic Effect/ADR for Clomipramine (DBSNPE005581)
- Identifier
- DBSNPE005581
- Drug
- Clomipramine (DB01242)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
-1426C>T Not Available -1235A>G Not Available -1000G>A Not Available 100C>T Not Available 310G>T Not Available CYP2D7 sequence from intron 1 onwards Not Available - Allele Name
- CYP2D6*68A
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
- References
- Kramer WE, Walker DL, O'Kane DJ, Mrazek DA, Fisher PK, Dukek BA, Bruflat JK, Black JL: CYP2D6: novel genomic structures and alleles. Pharmacogenet Genomics. 2009 Oct;19(10):813-22. doi: 10.1097/FPC.0b013e3283317b95. [PubMed:19741566]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]