Pharmacogenomic Effect/ADR for Codeine (DBSNPE005640)

Identifier
DBSNPE005640
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
4044C>TNot Available
Allele Name
CYP2D6*62
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements
References
  1. Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, Zanger UM: A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab Dispos. 2007 Aug;35(8):1247-50. Epub 2007 Apr 25. [PubMed:17460029]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]