Pharmacogenomic Effect/ADR for Desipramine (DBSNPE005651)

Identifier
DBSNPE005651
Drug
Desipramine (DB01151)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
2935A>Crs5030867
Allele Name
CYP2D6*7
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Evert B, Griese EU, Eichelbaum M: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):434-9. [PubMed:7845481]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]