Pharmacogenomic Effect/ADR for Desipramine (DBSNPE005653)

Identifier
DBSNPE005653
Drug
Desipramine (DB01151)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
883G>Crs5030863
Allele Name
CYP2D6*11
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Marez D, Sabbagh N, Legrand M, Lo-Guidice JM, Boone P, Broly F: A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogenetics. 1995 Oct;5(5):305-11. [PubMed:8563771]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]