Pharmacogenomic Effect/ADR for Desipramine (DBSNPE005663)

DocumentationBrowse all
Identifier
DBSNPE005663
Drug
Desipramine (DB01151)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
2587_2590delGACTrs72549351
Allele Name
CYP2D6*38
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Leathart JB, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. [PubMed:9918137]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]