- Identifier
- DBSNPE005663
- Drug
- Desipramine (DB01151)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
- Allele Name
- CYP2D6*38
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
- References
- Leathart JB, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. [PubMed:9918137]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]