Pharmacogenomic Effect/ADR for Desipramine (DBSNPE005664)

Identifier
DBSNPE005664
Drug
Desipramine (DB01151)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
1863_1864ins(TTT CGC CCC)2rs72549356
Allele Name
CYP2D6*40
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Gaedigk A, Bradford LD, Marcucci KA, Leeder JS: Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther. 2002 Jul;72(1):76-89. [PubMed:12152006]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]