Pharmacogenomic Effect/ADR for Desipramine (DBSNPE005672)

Identifier
DBSNPE005672
Drug
Desipramine (DB01151)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1426C>TNot Available
-1235A>GNot Available
-1000G>ANot Available
100C>TNot Available
310G>TNot Available
CYP2D7 sequence from intron 1 onwardsNot Available
Allele Name
CYP2D6*68A
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References
  1. Kramer WE, Walker DL, O'Kane DJ, Mrazek DA, Fisher PK, Dukek BA, Bruflat JK, Black JL: CYP2D6: novel genomic structures and alleles. Pharmacogenet Genomics. 2009 Oct;19(10):813-22. doi: 10.1097/FPC.0b013e3283317b95. [PubMed:19741566]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]