Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE005780)

Identifier
DBSNPE005780
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
681G>Ars4244285
Allele Name
CYP2C19*2B
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C19
Description
Poor metabolizer, lower dose requirement
References
  1. Ibeanu GC, Goldstein JA, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem BI, Blaisdell J: Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther. 1998 Sep;286(3):1490-5. [PubMed:9732415]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]