Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE005787)

Identifier
DBSNPE005787
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
99C>Trs17885098
991A>Grs3758581
1004G>Ars118203757
1197A>GNot Available
Allele Name
CYP2C19*24
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C19
Description
Poor metabolizer, lower dose requirement
References
  1. Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. Pharmacogenomics J. 2009 Dec;9(6):380-94. doi: 10.1038/tpj.2009.31. Epub 2009 Jul 28. [PubMed:19636337]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]