Pharmacogenomic Effect/ADR for Isoniazid (DBSNPE006065)

Identifier
DBSNPE006065
Drug
Isoniazid (DB00951)
Interacting Gene/Enzyme
Cytochrome P450 2E1
Gene Name
CYP2E1
UniProt ID
P05181
Defining Change(s)
Allele Name
CYP2E1*4
Genotype(s)
(A;A)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in CYP2E1 may be associated with an increased risk of drug-induced hepatotoxicity from isoniazid treatment.
References
  1. Vuilleumier N, Rossier MF, Chiappe A, Degoumois F, Dayer P, Mermillod B, Nicod L, Desmeules J, Hochstrasser D: CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. Eur J Clin Pharmacol. 2006 Jun;62(6):423-9. Epub 2006 Apr 27. [PubMed:16770646]