Pharmacogenomic Effect/ADR for Doxorubicin (DBSNPE006093)

Identifier
DBSNPE006093
Drug
Doxorubicin (DB00997)
Interacting Gene/Enzyme
UDP-glucuronosyltransferase 1-6
Gene Name
UGT1A6
UniProt ID
P19224
Defining Change(s)
G > Trs17863783
Allele Name
UGT1A6*4
Genotype(s)
(G;T) / (T;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Pediatric patients who carry this genotype may be at a higher risk of experiencing anthracycline-induced cardiotoxicity when treated with doxorubicin.
References
  1. Aminkeng F, Ross CJ, Rassekh SR, Hwang S, Rieder MJ, Bhavsar AP, Smith A, Sanatani S, Gelmon KA, Bernstein D, Hayden MR, Amstutz U, Carleton BC: Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity. Br J Clin Pharmacol. 2016 Sep;82(3):683-95. doi: 10.1111/bcp.13008. Epub 2016 Jun 30. [PubMed:27197003]