Glypican-1
Details
- Name
- Glypican-1
- Synonyms
- Not Available
- Gene Name
- GPC1
- Organism
- Bovine
- Amino acid sequence
>lcl|BSEQ0015708|Glypican-1 MELRARGWWLLYAAAVLVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLR ICPQGYTCCTSEMEENLANRSRAELETALLEGTRALQATLAAQQRGFDDHFQRLLNDSER ALQEAFPGAFGELYTQNAKAFRDLYAELRLYYGGANLHLQETLAEFWARLLERLFRQLHP QLLLPDDYLDCLGKQAEPLRPFGEAPRELRLRATRAFVAARTFVQGLGVAGDVVRKVAKV PLSPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLI TDKFWGPSGAESVVGGVHYWLAEAINALQDNSDTLTAKVIQGCGNPKVNPQGPGTEEKWP RGKLALQERPPAGTLQKLVSEAKAQLRDAQDFWISLPGTLCSEKLAMSSASDERCWNGMA KGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYNGNDLDFQD ASDDGSGSGSGEGCPDEMCGRKVGRKSASSRTPLTHALPGLSEREGQQTSAAAPTPPQAS PLLLLGLALALPAVAPRGR
- Number of residues
- 559
- Molecular Weight
- 61006.81
- Theoretical pI
- Not Available
- GO Classification
- Functionscopper ion binding / fibroblast growth factor binding / laminin bindingProcessesheparan sulfate proteoglycan catabolic process / negative regulation of fibroblast growth factor receptor signaling pathway / positive regulation of skeletal muscle cell differentiationComponentsanchored component of membrane / endosome / extracellular exosome / extracellular space / membrane raft / plasma membrane / proteinaceous extracellular matrix
- General Function
- Laminin binding
- Specific Function
- Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling (By similarity).
- Pfam Domain Function
- Glypican (PF01153)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0015709|Glypican-1 (GPC1) ATGGAGCTCCGGGCCCGAGGCTGGTGGCTGCTGTACGCGGCCGCCGTGCTGGTCGCCTGC GCCCGCGGGGACCCTGCCAGCAAGAGTCGGAGCTGCGGGGAAGTGCGCCAGATCTACGGG GCCAAGGGCTTCAGCCTGAGCGATGTGCCCCAGGCGGAGATCTCGGGCGAGCACCTGCGC ATCTGCCCCCAGGGCTACACCTGCTGCACCAGTGAGATGGAGGAGAACCTTGCCAACCGC AGCCGCGCTGAGCTGGAGACAGCACTTCTGGAGGGCACCCGGGCGCTGCAGGCCACGCTG GCCGCCCAGCAGCGGGGCTTTGACGATCACTTCCAGCGCCTGTTGAACGACTCGGAACGG GCGCTGCAGGAGGCCTTCCCGGGCGCCTTCGGAGAGCTGTACACGCAGAACGCCAAGGCC TTCCGCGACCTGTACGCCGAGCTGCGCCTCTACTACGGCGGCGCCAACCTGCACCTGCAG GAGACGCTGGCCGAGTTCTGGGCGCGCCTGCTCGAGCGCCTCTTCAGGCAGCTGCACCCG CAGCTGCTGCTGCCTGACGACTACCTGGACTGCCTGGGCAAGCAGGCCGAGCCGCTGCGG CCCTTCGGCGAGGCCCCCCGCGAGCTGCGCCTGCGCGCCACCCGCGCCTTCGTGGCGGCG CGCACCTTCGTGCAGGGCCTGGGCGTGGCCGGCGACGTGGTGCGCAAGGTGGCCAAGGTG CCCCTGAGCCCCGAGTGCTCGCGGGCCGTCATGAAGCTGGTGTACTGCGCCCACTGCCTT GGGGTGCCCGGCGCCCGGCCCTGCCCTGACTACTGCCGCAACGTGCTCAAGGGCTGCCTA GCCAACCAGGCCGACCTGGACGCAGAGTGGAGGAATCTTCTGGACTCCATGGTGCTCATC ACGGACAAGTTCTGGGGCCCGTCGGGCGCGGAGAGTGTCGTCGGCGGCGTGCACTACTGG CTGGCGGAGGCCATCAACGCCCTCCAGGACAACAGTGACACGCTCACAGCCAAGGTCATC CAGGGCTGCGGGAACCCCAAGGTGAACCCCCAGGGCCCCGGCACTGAGGAGAAGTGGCCC CGGGGCAAGCTGGCGCTGCAGGAGAGGCCACCCGCGGGCACGCTGCAGAAGCTGGTCTCC GAAGCCAAGGCCCAGCTCCGAGACGCTCAGGACTTCTGGATCAGCCTCCCGGGAACGCTG TGCAGTGAGAAGCTGGCCATGAGCTCGGCCAGTGACGAACGCTGCTGGAACGGCATGGCC AAGGGCCGGTACCTCCCCGAGGTGATGGGTGATGGCTTGGCCAATCAGATCAACAACCCC GAGGTGGAGGTGGACATCACCAAGCCCGACATGACCATCCGCCAGCAGATCATGCAGCTG AAGATCATGACCAACCGCCTGCGCGGCGCCTATAATGGCAACGATCTGGACTTCCAGGAC GCCAGCGACGACGGCAGCGGCTCGGGCAGCGGCGAGGGCTGCCCGGATGAGATGTGTGGC CGGAAGGTCGGCAGGAAGAGCGCCAGCTCGCGGACGCCGCTGACGCACGCCCTCCCGGGG CTGTCGGAGCGGGAGGGCCAGCAGACCTCAGCTGCGGCACCCACCCCGCCCCAGGCCAGT CCTCTGCTGCTCCTGGGGCTCGCCCTGGCCCTTCCGGCAGTTGCGCCCCGGGGGCGGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID G3X745 UniProtKB Entry Name GPC1_BOVIN - General References
- Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details