Glypican-1

Details

Name
Glypican-1
Synonyms
Not Available
Gene Name
GPC1
Organism
Bovine
Amino acid sequence
>lcl|BSEQ0015708|Glypican-1
MELRARGWWLLYAAAVLVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLR
ICPQGYTCCTSEMEENLANRSRAELETALLEGTRALQATLAAQQRGFDDHFQRLLNDSER
ALQEAFPGAFGELYTQNAKAFRDLYAELRLYYGGANLHLQETLAEFWARLLERLFRQLHP
QLLLPDDYLDCLGKQAEPLRPFGEAPRELRLRATRAFVAARTFVQGLGVAGDVVRKVAKV
PLSPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLI
TDKFWGPSGAESVVGGVHYWLAEAINALQDNSDTLTAKVIQGCGNPKVNPQGPGTEEKWP
RGKLALQERPPAGTLQKLVSEAKAQLRDAQDFWISLPGTLCSEKLAMSSASDERCWNGMA
KGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYNGNDLDFQD
ASDDGSGSGSGEGCPDEMCGRKVGRKSASSRTPLTHALPGLSEREGQQTSAAAPTPPQAS
PLLLLGLALALPAVAPRGR
Number of residues
559
Molecular Weight
61006.81
Theoretical pI
Not Available
GO Classification
Functions
copper ion binding / fibroblast growth factor binding / laminin binding
Processes
heparan sulfate proteoglycan catabolic process / negative regulation of fibroblast growth factor receptor signaling pathway / positive regulation of skeletal muscle cell differentiation
Components
anchored component of membrane / endosome / extracellular exosome / extracellular space / membrane raft / plasma membrane / proteinaceous extracellular matrix
General Function
Laminin binding
Specific Function
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0015709|Glypican-1 (GPC1)
ATGGAGCTCCGGGCCCGAGGCTGGTGGCTGCTGTACGCGGCCGCCGTGCTGGTCGCCTGC
GCCCGCGGGGACCCTGCCAGCAAGAGTCGGAGCTGCGGGGAAGTGCGCCAGATCTACGGG
GCCAAGGGCTTCAGCCTGAGCGATGTGCCCCAGGCGGAGATCTCGGGCGAGCACCTGCGC
ATCTGCCCCCAGGGCTACACCTGCTGCACCAGTGAGATGGAGGAGAACCTTGCCAACCGC
AGCCGCGCTGAGCTGGAGACAGCACTTCTGGAGGGCACCCGGGCGCTGCAGGCCACGCTG
GCCGCCCAGCAGCGGGGCTTTGACGATCACTTCCAGCGCCTGTTGAACGACTCGGAACGG
GCGCTGCAGGAGGCCTTCCCGGGCGCCTTCGGAGAGCTGTACACGCAGAACGCCAAGGCC
TTCCGCGACCTGTACGCCGAGCTGCGCCTCTACTACGGCGGCGCCAACCTGCACCTGCAG
GAGACGCTGGCCGAGTTCTGGGCGCGCCTGCTCGAGCGCCTCTTCAGGCAGCTGCACCCG
CAGCTGCTGCTGCCTGACGACTACCTGGACTGCCTGGGCAAGCAGGCCGAGCCGCTGCGG
CCCTTCGGCGAGGCCCCCCGCGAGCTGCGCCTGCGCGCCACCCGCGCCTTCGTGGCGGCG
CGCACCTTCGTGCAGGGCCTGGGCGTGGCCGGCGACGTGGTGCGCAAGGTGGCCAAGGTG
CCCCTGAGCCCCGAGTGCTCGCGGGCCGTCATGAAGCTGGTGTACTGCGCCCACTGCCTT
GGGGTGCCCGGCGCCCGGCCCTGCCCTGACTACTGCCGCAACGTGCTCAAGGGCTGCCTA
GCCAACCAGGCCGACCTGGACGCAGAGTGGAGGAATCTTCTGGACTCCATGGTGCTCATC
ACGGACAAGTTCTGGGGCCCGTCGGGCGCGGAGAGTGTCGTCGGCGGCGTGCACTACTGG
CTGGCGGAGGCCATCAACGCCCTCCAGGACAACAGTGACACGCTCACAGCCAAGGTCATC
CAGGGCTGCGGGAACCCCAAGGTGAACCCCCAGGGCCCCGGCACTGAGGAGAAGTGGCCC
CGGGGCAAGCTGGCGCTGCAGGAGAGGCCACCCGCGGGCACGCTGCAGAAGCTGGTCTCC
GAAGCCAAGGCCCAGCTCCGAGACGCTCAGGACTTCTGGATCAGCCTCCCGGGAACGCTG
TGCAGTGAGAAGCTGGCCATGAGCTCGGCCAGTGACGAACGCTGCTGGAACGGCATGGCC
AAGGGCCGGTACCTCCCCGAGGTGATGGGTGATGGCTTGGCCAATCAGATCAACAACCCC
GAGGTGGAGGTGGACATCACCAAGCCCGACATGACCATCCGCCAGCAGATCATGCAGCTG
AAGATCATGACCAACCGCCTGCGCGGCGCCTATAATGGCAACGATCTGGACTTCCAGGAC
GCCAGCGACGACGGCAGCGGCTCGGGCAGCGGCGAGGGCTGCCCGGATGAGATGTGTGGC
CGGAAGGTCGGCAGGAAGAGCGCCAGCTCGCGGACGCCGCTGACGCACGCCCTCCCGGGG
CTGTCGGAGCGGGAGGGCCAGCAGACCTCAGCTGCGGCACCCACCCCGCCCCAGGCCAGT
CCTCTGCTGCTCCTGGGGCTCGCCCTGGCCCTTCCGGCAGTTGCGCCCCGGGGGCGGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDG3X745
UniProtKB Entry NameGPC1_BOVIN
General References
  1. Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails