Cytochrome c-552
Details
- Name
- Cytochrome c-552
- Synonyms
- 1.7.2.2
- Cytochrome c nitrite reductase
- TvNiR
- Gene Name
- nir
- Organism
- Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 / ALEN2)
- Amino acid sequence
>lcl|BSEQ0019555|Cytochrome c-552 MNDLNRLGRVGRWIAGAACLFLASAAHAEPGENLKPVDAMQCFDCHTQIEDMHTVGKHAT VNCVHCHDATEHVETASSRRMGERPVTRMDLEACATCHTAQFNSFVEVRHESHPRLEKAT PTSRSPMFDKLIAGHGFAFEHAEPRSHAFMLVDHFVVDRAYGGRFQFKNWQKVTDGMGAV RGAWTVLTDADPESSDQRRFLSQTATAANPVCLNCKTQDHILDWAYMGDEHEAAKWSRTS EVVEFARDLNHPLNCFMCHDPHSAGPRVVRDGLINAVVDRGLGTYPHDPVKSEQQGMTKV TFQRGREDFRAIGLLDTADSNVMCAQCHVEYNCNPGYQLSDGSRVGMDDRRANHFFWANV FDYKEAAQEIDFFDFRHATTGAALPKLQHPEAETFWGSVHERNGVACADCHMPKVQLENG KVYTSHSQRTPRDMMGQACLNCHAEWTEDQALYAIDYIKNYTHGKIVKSEYWLAKMIDLF PVAKRAGVSEDVLNQARELHYDAHLYWEWWTAENSVGFHNPDQARESLMTSISKSKEAVS LLNDAIDAQVASR
- Number of residues
- 553
- Molecular Weight
- 62344.36
- Theoretical pI
- 6.35
- GO Classification
- Functionscalcium ion binding / heme binding / nitrite reductase (cytochrome, ammonia-forming) activityProcessesammonium ion metabolic process / nitrate assimilationComponentsperiplasmic space
- General Function
- Nitrite reductase (cytochrome, ammonia-forming) activity
- Specific Function
- Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process (PubMed:16500161, PubMed:22281743). Has very low activity toward hydroxylamine (PubMed:16500161). Has even lower activity toward sulfite (PubMed:16500161, PubMed:22281743). Sulfite reductase activity is maximal at neutral pH (PubMed:20944237).
- Pfam Domain Function
- Cytochrom_C552 (PF02335)
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0019556|Cytochrome c-552 (nir) ATGAATGATCTCAACAGACTCGGCCGTGTGGGCCGATGGATTGCGGGGGCAGCCTGTCTG TTCCTTGCCTCTGCCGCTCACGCGGAACCGGGGGAGAACCTCAAACCCGTGGATGCGATG CAGTGCTTCGACTGCCACACGCAGATCGAGGACATGCACACAGTTGGCAAGCACGCCACC GTGAACTGTGTCCACTGTCACGATGCTACCGAGCACGTCGAAACGGCCAGCAGCCGCCGC ATGGGCGAACGGCCCGTTACACGCATGGATCTGGAGGCCTGCGCTACCTGCCATACCGCA CAGTTCAATTCCTTCGTTGAAGTGCGCCACGAGTCGCACCCGCGCTTGGAGAAGGCGACG CCGACGAGTCGGTCGCCGATGTTCGACAAGCTGATCGCCGGTCACGGTTTCGCGTTCGAG CACGCCGAACCGCGCAGTCACGCGTTCATGCTGGTCGATCACTTTGTCGTCGACCGCGCT TATGGCGGCCGCTTCCAGTTCAAGAACTGGCAGAAGGTCACCGACGGCATGGGGGCGGTT CGCGGCGCCTGGACAGTGCTGACCGATGCCGACCCCGAGAGCTCGGACCAGCGCCGGTTC CTGTCGCAGACGGCCACCGCCGCAAACCCGGTGTGCCTGAACTGCAAGACGCAGGACCAT ATCCTTGACTGGGCCTACATGGGTGACGAGCACGAAGCGGCCAAGTGGAGCCGGACCTCG GAGGTGGTCGAGTTCGCGCGTGACTTGAACCATCCGCTGAACTGCTTCATGTGCCATGAC CCGCATTCGGCCGGTCCGCGCGTCGTGCGTGACGGCCTGATCAATGCGGTTGTCGACCGC GGGCTCGGGACCTACCCGCATGACCCGGTGAAAAGCGAACAGCAGGGCATGACCAAGGTC ACGTTCCAGCGCGGCCGCGAGGACTTCCGGGCGATCGGCCTGCTCGATACGGCGGATTCC AACGTGATGTGCGCCCAGTGCCACGTGGAGTACAACTGCAACCCGGGTTACCAGTTGAGT GACGGGTCGCGGGTCGGCATGGACGATCGTCGCGCCAACCACTTCTTCTGGGCCAACGTG TTCGACTACAAGGAAGCCGCGCAGGAGATCGACTTCTTCGATTTCCGGCATGCCACCACC GGAGCGGCGCTGCCGAAGCTGCAGCATCCGGAGGCCGAGACGTTCTGGGGCTCTGTCCAC GAGCGCAACGGCGTCGCCTGCGCCGACTGCCACATGCCCAAGGTTCAGCTGGAAAACGGC AAGGTCTACACCAGCCACAGCCAGCGCACGCCGCGTGACATGATGGGCCAGGCGTGTCTG AACTGCCATGCGGAGTGGACCGAGGATCAGGCCCTGTACGCGATCGACTACATCAAGAAC TACACTCACGGCAAGATCGTCAAATCCGAGTACTGGCTTGCCAAGATGATCGACCTGTTC CCGGTCGCGAAGCGGGCTGGCGTGTCGGAGGATGTTCTGAACCAGGCGCGTGAGCTGCAC TACGACGCACACCTGTACTGGGAGTGGTGGACCGCGGAAAACTCCGTCGGTTTCCACAAC CCCGATCAGGCGCGTGAGTCGCTGATGACCTCGATCAGCAAGAGCAAGGAAGCCGTTAGC CTGCTGAATGACGCAATCGACGCCCAGGTGGCTTCGAGATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID L0DSL2 UniProtKB Entry Name NIR_THIND GenBank Protein ID 73661133 GenBank Gene ID AJ880678 - General References
- Tikhonova TV, Slutsky A, Antipov AN, Boyko KM, Polyakov KM, Sorokin DY, Zvyagilskaya RA, Popov VO: Molecular and catalytic properties of a novel cytochrome c nitrite reductase from nitrate-reducing haloalkaliphilic sulfur-oxidizing bacterium Thioalkalivibrio nitratireducens. Biochim Biophys Acta. 2006 Apr;1764(4):715-23. Epub 2006 Feb 9. [Article]
- Polyakov KM, Boyko KM, Tikhonova TV, Slutsky A, Antipov AN, Zvyagilskaya RA, Popov AN, Bourenkov GP, Lamzin VS, Popov VO: High-resolution structural analysis of a novel octaheme cytochrome c nitrite reductase from the haloalkaliphilic bacterium Thioalkalivibrio nitratireducens. J Mol Biol. 2009 Jun 26;389(5):846-62. doi: 10.1016/j.jmb.2009.04.037. Epub 2009 Apr 23. [Article]
- Trofimov AA, Polyakov KM, Boyko KM, Tikhonova TV, Safonova TN, Tikhonov AV, Popov AN, Popov VO: Structures of complexes of octahaem cytochrome c nitrite reductase from Thioalkalivibrio nitratireducens with sulfite and cyanide. Acta Crystallogr D Biol Crystallogr. 2010 Oct;66(Pt 10):1043-7. doi: 10.1107/S0907444910031665. Epub 2010 Sep 18. [Article]
- Trofimov AA, Polyakov KM, Tikhonova TV, Tikhonov AV, Safonova TN, Boyko KM, Dorovatovskii PV, Popov VO: Covalent modifications of the catalytic tyrosine in octahaem cytochrome c nitrite reductase and their effect on the enzyme activity. Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):144-53. doi: 10.1107/S0907444911052632. Epub 2012 Jan 13. [Article]