Bone morphogenetic protein receptor type-1B
Details
- Name
- Bone morphogenetic protein receptor type-1B
- Synonyms
- 2.7.11.30
- BMP type-1B receptor
- Gene Name
- BMPR1B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051708|Bone morphogenetic protein receptor type-1B MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS RLTALRVKKTLAKMSESQDIKL
- Number of residues
- 502
- Molecular Weight
- 56929.905
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / metal ion binding / protein serine/threonine kinase activity / signal transducer, downstream of receptor, with serine/threonine kinase activity / SMAD binding / transforming growth factor beta receptor activity, type I / transmembrane receptor protein serine/threonine kinase activityProcessesBMP signaling pathway / cartilage condensation / cellular response to BMP stimulus / chondrocyte development / dorsal/ventral pattern formation / endochondral bone morphogenesis / eye development / inflammatory response / limb morphogenesis / negative regulation of chondrocyte proliferation / ovarian cumulus expansion / ovulation cycle / positive regulation of bone mineralization / positive regulation of cartilage development / positive regulation of cell differentiation / positive regulation of chondrocyte differentiation / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of osteoblast differentiation / positive regulation of transcription by RNA polymerase II / protein phosphorylation / proteoglycan biosynthetic process / retina development in camera-type eye / retinal ganglion cell axon guidance / skeletal system developmentComponentsdendrite / HFE-transferrin receptor complex / integral component of plasma membrane / neuronal cell body / plasma membrane / receptor complex
- General Function
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- 127-148
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0051709|Bone morphogenetic protein receptor type-1B (BMPR1B) ATGCTTTTGCGAAGTGCAGGAAAATTAAATGTGGGCACCAAGAAAGAGGATGGTGAGAGT ACAGCCCCCACCCCCCGTCCAAAGGTCTTGCGTTGTAAATGCCACCACCATTGTCCAGAA GACTCAGTCAACAATATTTGCAGCACAGACGGATATTGTTTCACGATGATAGAAGAGGAT GACTCTGGGTTGCCTGTGGTCACTTCTGGTTGCCTAGGACTAGAAGGCTCAGATTTTCAG TGTCGGGACACTCCCATTCCTCATCAAAGAAGATCAATTGAATGCTGCACAGAAAGGAAC GAATGTAATAAAGACCTACACCCTACACTGCCTCCATTGAAAAACAGAGATTTTGTTGAT GGACCTATACACCACAGGGCTTTACTTATATCTGTGACTGTCTGTAGTTTGCTCTTGGTC CTTATCATATTATTTTGTTACTTCCGGTATAAAAGACAAGAAACCAGACCTCGATACAGC ATTGGGTTAGAACAGGATGAAACTTACATTCCTCCTGGAGAATCCCTGAGAGACTTAATT GAGCAGTCTCAGAGCTCAGGAAGTGGATCAGGCCTCCCTCTGCTGGTCCAAAGGACTATA GCTAAGCAGATTCAGATGGTGAAACAGATTGGAAAAGGTCGCTATGGGGAAGTTTGGATG GGAAAGTGGCGTGGCGAAAAGGTAGCTGTGAAAGTGTTCTTCACCACAGAGGAAGCCAGC TGGTTCAGAGAGACAGAAATATATCAGACAGTGTTGATGAGGCATGAAAACATTTTGGGT TTCATTGCTGCAGATATCAAAGGGACAGGGTCCTGGACCCAGTTGTACCTAATCACAGAC TATCATGAAAATGGTTCCCTTTATGATTATCTGAAGTCCACCACCCTAGACGCTAAATCA ATGCTGAAGTTAGCCTACTCTTCTGTCAGTGGCTTATGTCATTTACACACAGAAATCTTT AGTACTCAAGGCAAACCAGCAATTGCCCATCGAGATCTGAAAAGTAAAAACATTCTGGTG AAGAAAAATGGAACTTGCTGTATTGCTGACCTGGGCCTGGCTGTTAAATTTATTAGTGAT ACAAATGAAGTTGACATACCACCTAACACTCGAGTTGGCACCAAACGCTATATGCCTCCA GAAGTGTTGGACGAGAGCTTGAACAGAAATCACTTCCAGTCTTACATCATGGCTGACATG TATAGTTTTGGCCTCATCCTTTGGGAGGTTGCTAGGAGATGTGTATCAGGAGGTATAGTG GAAGAATACCAGCTTCCTTATCATGACCTAGTGCCCAGTGACCCCTCTTATGAGGACATG AGGGAGATTGTGTGCATCAAGAAGTTACGCCCCTCATTCCCAAACCGGTGGAGCAGTGAT GAGTGTCTAAGGCAGATGGGAAAACTCATGACAGAATGCTGGGCTCACAATCCTGCATCA AGGCTGACAGCCCTGCGGGTTAAGAAAACACTTGCCAAAATGTCAGAGTCCCAGGACATT AAACTCTGA
- Chromosome Location
- 4
- Locus
- 4q22.3
- External Identifiers
Resource Link UniProtKB ID O00238 UniProtKB Entry Name BMR1B_HUMAN HGNC ID HGNC:1077 - General References
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