Inositol phosphorylceramide synthase
Details
- Name
- Inositol phosphorylceramide synthase
- Synonyms
- 2.-.-.-
- Aureobasidin A resistance protein homolog
- IPC synthase
- Phosphatidylinositol:ceramide phosphoinositol transferase
- Gene Name
- AUR1
- Organism
- Yeast
- Amino acid sequence
>lcl|BSEQ0051975|Inositol phosphorylceramide synthase MASSILRSKIIQKPYQLFHYYFLSEKAPGSTVSDLNFDTNIQTSLRKLKHHHWTVGEIFH YGFLVSILFFVFVVFPASFFIKLPIILAFATCFLIPLTSQFFLPALPVFTWLALYFTCAK IPQEWKPAITVKVLPAMETILYGDNLSNVLATITTGVLDILAWLPYGIIHFSFPFVLAAI IFLFGPPTALRSFGFAFGYMNLLGVLIQMAFPAAPPWYKNLHGLEPANYSMHGSPGGLGR IDKLLGVDMYTTGFSNSSIIFGAFPSLHSGCCIMEVLFLCWLFPRFKFVWVTYASWLWWS TMYLTHHYFVDLIGGAMLSLTVFEFTKYKYLPKNKEGLFCRWSYTEIEKIDIQEIDPLSY NYIPINSNDNESRLYTRVYQESQVSPPSRAETPEAFEMSNFSRSRQSSKTQVPLSNLTNN DQVPGINEEDEEEEGDEISSSTPSVFEDEPQGSTYAASSATSVDDLDSKRN
- Number of residues
- 471
- Molecular Weight
- 53457.9
- Theoretical pI
- Not Available
- GO Classification
- Functionsinositol phosphoceramide synthase activityProcessescellular response to drug / sphingolipid metabolic processComponentsGolgi cisterna membrane / integral component of membrane
- General Function
- Catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.
- Specific Function
- Inositol phosphoceramide synthase activity
- Pfam Domain Function
- PAP2_3 (PF14378)
- Transmembrane Regions
- 55-75 78-98 101-121 169-189 192-212 259-279 282-302 305-325
- Cellular Location
- Golgi apparatus
- Gene sequence
>lcl|BSEQ0051976|Inositol phosphorylceramide synthase (AUR1) ATGGCATCTTCTATTTTGCGTTCCAAAATAATACAAAAACCGTACCAATTATTCCACTAC TATTTTCTTCTGGAGAAGGCTCCTGGTTCTACAGTTAGTGATTTGAATTTTGATACAAAC ATACAAACGAGTTTACGTAAATTAAAGCATCATCATTGGACGGTGGGAGAAATATTCCAT TATGGGTTTTTGGTTTCCATACTTTTTTTCGTGTTTGTGGTTTTCCCAGCTTCATTTTTT ATAAAATTACCAATAATCTTAGCATTTGCTACTTGTTTTTTAATACCCTTAACATCACAA TTTTTTCTTCCTGCCTTGCCCGTTTTCACTTGGTTGGCATTATATTTTACGTGTGCTAAA ATACCTCAAGAATGGAAACCAGCTATCACAGTTAAAGTTTTACCAGCTATGGAAACAATT TTGTACGGCGATAATTTATCAAATGTTTTGGCAACCATCACTACCGGAGTGTTAGATATA TTGGCATGGTTACCATATGGGATTATTCATTTCAGTTTCCCATTTGTACTTGCTGCTATT ATATTTTTATTTGGGCCACCGACGGCATTAAGATCATTTGGGTTTGCCTTTGGTTATATG AACTTGCTTGGAGTCTTGATTCAAATGGCATTCCCAGCTGCTCCTCCATGGTACAAAAAC TTGCACGGATTAGAACCAGCTAATTATTCAATGCACGGGTCTCCTGGTGGACTTGGAAGG ATAGATAAATTGTTAGGTGTTGATATGTATACCACCGGATTTTCCAATTCATCAATCATT TTTGGGGCATTCCCATCGTTACATTCAGGATGTTGTATCATGGAAGTGTTATTTTTGTGT TGGTTGTTTCCACGATTCAAGTTTGTGTGGGTTACATACGCATCTTGGCTTTGGTGGAGC ACGATGTATTTGACTCATCACTACTTTGTCGATTTGATTGGTGGAGCCATGTTATCTTTG ACTGTTTTTGAATTCACTAAATATAAATATTTGCCAAAAAACAAAGAAGGCCTTTTCTGT CGTTGGTCATACACTGAAATTGAAAAAATCGATATCCAAGAAATTGACCCTTTATCATAC AATTATATCCCTATCAACAGCAATGATAATGAAAGCAGATTGTATACGAGAGTGTACCAA GAGTCTCAGGTTAGTCCCCCACTGAGAGCTGAAACACCTGAAGCATTTGAGATGTCAAAT TTTTCTAGGTCCAGACAAAGCTCAAAGACTCAGGTTCCATTGAGTAATCTTACTAACAAT GATCAAGTGCCTGGAATTAACGAAGAGGATGAAGAAGAAGAAGGCGATGAAATTTCGTCG AGTACTCCTTCGGTGTTTGAAGACGAACCACAGGGTAGCACATATGCTGCATCCTCAGCT ACATCAGTAGATGATTTGGATTCCAAAAGAAATTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O13332 UniProtKB Entry Name AUR1_CANAL - General References
- Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. Epub 2004 May 3. [Article]
- van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT: Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52. [Article]
- Muzzey D, Schwartz K, Weissman JS, Sherlock G: Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97. [Article]
- Aeed PA, Young CL, Nagiec MM, Elhammer AP: Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother. 2009 Feb;53(2):496-504. doi: 10.1128/AAC.00633-08. Epub 2008 Dec 1. [Article]