Zinc transporter 4
Details
- Name
- Zinc transporter 4
- Synonyms
- Solute carrier family 30 member 4
- ZnT-4
- ZNT4
- Gene Name
- SLC30A4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052335|Zinc transporter 4 MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPER PVNGAHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVL YLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLE VLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSG HRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPE YKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDL NIWSLTSGKSTAIVHIQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRT CANCQSSSP
- Number of residues
- 429
- Molecular Weight
- 47482.24
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcessesregulation of sequestering of zinc ion / response to toxic substance / response to zinc ion / zinc ion homeostasis / zinc ion transmembrane transportComponentscytoplasm / integral component of membrane / late endosome / late endosome membrane / lysosomal membrane / membrane / plasma membrane
- General Function
- Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.
- Specific Function
- Zinc ion transmembrane transporter activity
- Pfam Domain Function
- Cation_efflux (PF01545)
- Transmembrane Regions
- 114-134 144-164 179-199 217-237 275-295 311-331
- Cellular Location
- Endosome membrane
- Gene sequence
>lcl|BSEQ0052336|Zinc transporter 4 (SLC30A4) ATGGCCGGCTCTGGCGCGTGGAAGCGCCTCAAATCTATGCTAAGGAAGGATGATGCGCCG CTGTTTTTAAATGACACCAGCGCCTTTGACTTCTCGGATGAGGCGGGGGACGAGGGGCTT TCTCGGTTCAACAAACTTCGAGTTGTGGTGGCCGATGACGGTTCCGAAGCCCCGGAAAGG CCTGTTAACGGGGCGCACCCGACCCTCCAGGCCGACGATGATTCCTTACTGGACCAAGAC TTACCTTTGACCAACAGTCAGCTGAGTTTGAAGGTGGACTCCTGTGACAACTGCAGCAAA CAGAGAGAGATACTGAAGCAGAGAAAGGTGAAAGCCAGGTTGACCATTGCTGCCGTTCTG TACTTGCTTTTCATGATTGGAGAACTTGTAGGTGGATACATTGCAAATAGCCTAGCAATC ATGACAGATGCACTTCATATGTTAACTGACCTAAGCGCCATCATACTCACCCTGCTTGCT TTGTGGCTATCATCAAAATCACCAACCAAAAGATTCACCTTTGGATTTCATCGCTTAGAG GTTTTGTCAGCTATGATTAGTGTGCTGTTGGTGTATATACTTATGGGATTCCTCTTATAT GAAGCTGTGCAAAGAACTATCCATATGAACTATGAAATAAATGGAGATATAATGCTCATC ACCGCAGCTGTTGGAGTTGCAGTTAATGTAATAATGGGGTTTCTGTTGAACCAGTCTGGT CACCGTCACTCCCATTCCCACTCCCTGCCTTCAAATTCCCCTACCAGAGGTTCTGGGTGT GAACGTAACCATGGGCAGGATAGCCTGGCAGTGAGAGCTGCATTTGTACATGCTTTGGGA GATTTGGTACAGAGTGTTGGTGTGCTAATAGCTGCATACATCATACGATTCAAGCCAGAA TACAAGATTGCTGACCCCATCTGTACATACGTATTTTCATTACTTGTGGCTTTTACAACA TTTCGAATCATATGGGATACAGTAGTTATAATACTAGAAGGTGTGCCAAGCCATTTGAAT GTAGACTATATCAAAGAAGCCTTGATGAAAATAGAAGATGTATATTCAGTCGAAGATTTA AATATCTGGTCTCTCACTTCAGGAAAATCTACTGCCATAGTTCACATACAGCTAATTCCT GGAAGTTCATCTAAATGGGAGGAAGTACAGTCCAAAGCAAACCATTTATTATTGAACACA TTTGGCATGTATAGATGTACTATTCAGCTTCAGAGTTACAGGCAAGAAGTGGACAGAACT TGTGCAAATTGTCAGAGTTCTAGTCCCTAA
- Chromosome Location
- 15
- Locus
- 15q21.1
- External Identifiers
Resource Link UniProtKB ID O14863 UniProtKB Entry Name ZNT4_HUMAN HGNC ID HGNC:11015 - General References
- Huang L, Gitschier J: A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet. 1997 Nov;17(3):292-7. doi: 10.1038/ng1197-292. [Article]
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- Falcon-Perez JM, Dell'Angelica EC: Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007 Apr 15;313(7):1473-83. doi: 10.1016/j.yexcr.2007.02.006. Epub 2007 Feb 15. [Article]