Tumor protein p73

Details

Name
Tumor protein p73
Synonyms
  • p53-like transcription factor
  • p53-related protein
  • P73
Gene Name
TP73
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049702|Tumor protein p73
MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTS
VMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTD
YPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPV
YKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPY
EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGR
DRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVR
GRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGG
MNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSH
CTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRG
GPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH
Number of residues
636
Molecular Weight
69622.865
Theoretical pI
Not Available
GO Classification
Functions
chromatin binding / damaged DNA binding / identical protein binding / MDM2/MDM4 family protein binding / metal ion binding / p53 binding / protein kinase binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II transcription factor activity, sequence-specific DNA binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Processes
activation of MAPK activity / cell cycle arrest / cellular response to DNA damage stimulus / cellular response to UV / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / intrinsic apoptotic signaling pathway in response to DNA damage / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / kidney development / mismatch repair / mitotic G1 DNA damage checkpoint / negative regulation of cardiac muscle cell proliferation / negative regulation of cell proliferation / negative regulation of JUN kinase activity / negative regulation of neuron apoptotic process / negative regulation of neuron differentiation / negative regulation of transcription from RNA polymerase II promoter / positive regulation of cell cycle arrest / positive regulation of oligodendrocyte differentiation / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / protein tetramerization / regulation of apoptotic process / regulation of gene expression / regulation of mitotic cell cycle / regulation of signal transduction by p53 class mediator / response to drug / response to gamma radiation / response to organonitrogen compound / response to X-ray / viral process
Components
cell junction / chromatin / cytosol / Golgi apparatus / intracellular membrane-bounded organelle / mitochondrion / nucleoplasm / nucleus / transcription factor complex
General Function
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Specific Function
Chromatin binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049703|Tumor protein p73 (TP73)
ATGGCCCAGTCCACCGCCACCTCCCCTGATGGGGGCACCACGTTTGAGCACCTCTGGAGC
TCTCTGGAACCAGACAGCACCTACTTCGACCTTCCCCAGTCAAGCCGGGGGAATAATGAG
GTGGTGGGCGGAACGGATTCCAGCATGGACGTCTTCCACCTGGAGGGCATGACTACATCT
GTCATGGCCCAGTTCAATCTGCTGAGCAGCACCATGGACCAGATGAGCAGCCGCGCGGCC
TCGGCCAGCCCCTACACCCCAGAGCACGCCGCCAGCGTGCCCACCCACTCGCCCTACGCA
CAACCCAGCTCCACCTTCGACACCATGTCGCCGGCGCCTGTCATCCCCTCCAACACCGAC
TACCCCGGACCCCACCACTTTGAGGTCACTTTCCAGCAGTCCAGCACGGCCAAGTCAGCC
ACCTGGACGTACTCCCCGCTCTTGAAGAAACTCTACTGCCAGATCGCCAAGACATGCCCC
ATCCAGATCAAGGTGTCCACCCCGCCACCCCCAGGCACCGCCATCCGGGCCATGCCTGTT
TACAAGAAAGCGGAGCACGTGACCGACGTCGTGAAACGCTGCCCCAACCACGAGCTCGGG
AGGGACTTCAACGAAGGACAGTCTGCTCCAGCCAGCCACCTCATCCGCGTGGAAGGCAAT
AATCTCTCGCAGTATGTGGATGACCCTGTCACCGGCAGGCAGAGCGTCGTGGTGCCCTAT
GAGCCACCACAGGTGGGGACGGAATTCACCACCATCCTGTACAACTTCATGTGTAACAGC
AGCTGTGTAGGGGGCATGAACCGGCGGCCCATCCTCATCATCATCACCCTGGAGATGCGG
GATGGGCAGGTGCTGGGCCGCCGGTCCTTTGAGGGCCGCATCTGCGCCTGTCCTGGCCGC
GACCGAAAAGCTGATGAGGACCACTACCGGGAGCAGCAGGCCCTGAACGAGAGCTCCGCC
AAGAACGGGGCCGCCAGCAAGCGTGCCTTCAAGCAGAGCCCCCCTGCCGTCCCCGCCCTT
GGTGCCGGTGTGAAGAAGCGGCGGCATGGAGACGAGGACACGTACTACCTTCAGGTGCGA
GGCCGGGAGAACTTTGAGATCCTGATGAAGCTGAAAGAGAGCCTGGAGCTGATGGAGTTG
GTGCCGCAGCCACTGGTGGACTCCTATCGGCAGCAGCAGCAGCTCCTACAGAGGCCGAGT
CACCTACAGCCCCCGTCCTACGGGCCGGTCCTCTCGCCCATGAACAAGGTGCACGGGGGC
ATGAACAAGCTGCCCTCCGTCAACCAGCTGGTGGGCCAGCCTCCCCCGCACAGTTCGGCA
GCTACACCCAACCTGGGGCCCGTGGGCCCCGGGATGCTCAACAACCATGGCCACGCAGTG
CCAGCCAACGGCGAGATGAGCAGCAGCCACAGCGCCCAGTCCATGGTCTCGGGGTCCCAC
TGCACTCCGCCACCCCCCTACCACGCCGACCCCAGCCTCGTCAGTTTTTTAACAGGATTG
GGGTGTCCAAACTGCATCGAGTATTTCACCTCCCAAGGGTTACAGAGCATTTACCACCTG
CAGAACCTGACCATTGAGGACCTGGGGGCCCTGAAGATCCCCGAGCAGTACCGCATGACC
ATCTGGCGGGGCCTGCAGGACCTGAAGCAGGGCCACGACTACAGCACCGCGCAGCAGCTG
CTCCGCTCTAGCAACGCGGCCACCATCTCCATCGGCGGCTCAGGGGAACTGCAGCGCCAG
CGGGTCATGGAGGCCGTGCACTTCCGCGTGCGCCACACCATCACCATCCCCAACCGCGGC
GGCCCAGGCGGCGGCCCTGACGAGTGGGCGGACTTCGGCTTCGACCTGCCCGACTGCAAG
GCCCGCAAGCAGCCCATCAAGGAGGAGTTCACGGAGGCCGAGATCCACTGA
Chromosome Location
1
Locus
1p36.32
External Identifiers
ResourceLink
UniProtKB IDO15350
UniProtKB Entry NameP73_HUMAN
HGNC IDHGNC:12003
General References
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  2. Mai M, Huang H, Reed C, Qian C, Smith JS, Alderete B, Jenkins R, Smith DI, Liu W: Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. Genomics. 1998 Aug 1;51(3):359-63. [PubMed:9721206]
  3. De Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, Levrero M, Melino G: Two new p73 splice variants, gamma and delta, with different transcriptional activity. J Exp Med. 1998 Nov 2;188(9):1763-8. [PubMed:9802988]
  4. De Laurenzi VD, Catani MV, Terrinoni A, Corazzari M, Melino G, Costanzo A, Levrero M, Knight RA: Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta. Cell Death Differ. 1999 May;6(5):389-90. [PubMed:10381648]
  5. Yoshikawa H, Nagashima M, Khan MA, McMenamin MG, Hagiwara K, Harris CC: Mutational analysis of p73 and p53 in human cancer cell lines. Oncogene. 1999 Jun 3;18(22):3415-21. [PubMed:10362363]
  6. Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A: Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001 Dec;8(12):1213-23. [PubMed:11753569]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01593Zincapproved, investigationalunknowncofactorDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails