Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Details

Name
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms
  • 1.3.1.9
  • ENR
  • NADH-dependent enoyl-ACP reductase
Gene Name
fabI
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Amino acid sequence
>lcl|BSEQ0016553|Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
MGFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYV
YELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISV
YSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHH
IRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGVS
GEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ
Number of residues
275
Molecular Weight
29981.18
Theoretical pI
7.8
GO Classification
Functions
enoyl-[acyl-carrier-protein] reductase (NADH) activity
Processes
fatty acid elongation / protein homotetramerization
General Function
Enoyl-[acyl-carrier-protein] reductase (nadh) activity
Specific Function
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
Pfam Domain Function
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cell inner membrane; peripheral membrane protein
Gene sequence
>lcl|BSEQ0016554|Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (fabI)
ATGGGATTTTTAAAAGGTAAAAAAGGGCTTATTGTAGGGGTGGCGAACAATAAATCCATC
GCTTATGGGATCGCTCAATCTTGTTTCAATCAAGGGGCTACTTTGGCTTTCACTTATTTG
AATGAGAGTTTAGAAAAGCGCGTAAGGCCTATCGCGCAGGAATTGAATAGCCCCTATGTG
TATGAATTGGATGTGAGCAAAGAAGAGCATTTCAAGTCGCTATACAATAGCGTTAAAAAG
GATTTAGGCTCATTGGATTTTATTGTTCATAGCGTGGCCTTTGCCCCTAAAGAGGCTTTA
GAGGGGAGCTTGTTGGAAACTTCTAAAAGCGCGTTTAACACCGCTATGGAAATTTCTGTT
TATTCTTTAATAGAGCTGACAAACACCCTAAAACCTTTATTGAATAACGGAGCGTCTGTT
TTGACTCTAAGCTATTTGGGTAGCACCAAATACATGGCGCATTACAATGTGATGGGGTTG
GCTAAAGCGGCCCTAGAGAGTGCGGTGCGTTATTTAGCGGTGGATTTAGGCAAACACCAT
ATAAGAGTGAATGCCCTATCGGCCGGGCCTATTAGGACGCTCGCTTCTAGCGGGATCGCT
GATTTTAGAATGATTTTAAAATGGAATGAAATCAACGCCCCTTTAAGAAAAAATGTGAGT
TTAGAAGAAGTGGGCAATGCCGGGATGTATTTGCTCTCTAGTTTGTCTAGCGGGGTGAGT
GGGGAAGTGCATTTTGTGGATGCTGGCTATCATGTTATGGGCATGGGGGCTGTGGAAGAA
AAAGATAATAAAGCTACGCTACTGTGGGATTTGCATAAAGAACAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO24990
UniProtKB Entry NameFABI_HELPY
GenBank Protein ID2313282
GenBank Gene IDAE000511
General References
  1. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]
  2. Lee HH, Moon J, Suh SW: Crystal structure of the Helicobacter pylori enoyl-acyl carrier protein reductase in complex with hydroxydiphenyl ether compounds, triclosan and diclosan. Proteins. 2007 Nov 15;69(3):691-4. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04393SoneclosanexperimentalunknownDetails
DB08604Triclosanapproved, investigationalunknownDetails