S-ribosylhomocysteine lyase

Details

Name
S-ribosylhomocysteine lyase
Synonyms
  • 4.4.1.21
  • AI-2 synthesis protein
  • Autoinducer-2 production protein LuxS
  • ytjB
Gene Name
luxS
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0011058|S-ribosylhomocysteine lyase
MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPNKQAMKPDTIHTLEHLL
AFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIVDLLEDTMKEAVEITEIPA
ANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG
Number of residues
157
Molecular Weight
17714.11
Theoretical pI
5.25
GO Classification
Functions
iron ion binding / S-ribosylhomocysteine lyase activity
Processes
quorum sensing
General Function
S-ribosylhomocysteine lyase activity
Specific Function
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011059|S-ribosylhomocysteine lyase (luxS)
ATGCCTTCAGTAGAAAGTTTTGAGCTTGATCATAATGCGGTTGTTGCTCCATATGTAAGA
CATTGCGGCGTGCATAAAGTGGGAACAGACGGCGTTGTAAATAAATTTGACATTCGTTTT
TGCCAGCCAAATAAACAGGCGATGAAGCCTGACACCATTCACACACTCGAGCATTTGCTC
GCGTTTACGATTCGTTCTCACGCTGAGAAATACGATCATTTTGATATCATTGATATTTCT
CCAATGGGCTGCCAGACAGGCTATTATCTAGTTGTGAGCGGAGAGCCGACATCAGCGGAA
ATCGTTGATCTGCTTGAAGACACAATGAAGGAAGCGGTAGAGATTACAGAAATACCTGCT
GCGAATGAAAAGCAGTGCGGCCAAGCGAAGCTTCATGATCTGGAAGGCGCTAAACGTTTA
ATGCGTTTCTGGCTTTCACAGGATAAAGAAGAATTGCTAAAAGTATTTGGCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO34667
UniProtKB Entry NameLUXS_BACSU
GenBank Protein ID2293157
GenBank Gene IDAF008220
General References
  1. Lapidus A, Galleron N, Sorokin A, Ehrlich SD: Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region. Microbiology. 1997 Nov;143 ( Pt 11):3431-41. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Zhu J, Dizin E, Hu X, Wavreille AS, Park J, Pei D: S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein. Biochemistry. 2003 Apr 29;42(16):4717-26. [Article]
  4. Ruzheinikov SN, Das SK, Sedelnikova SE, Hartley A, Foster SJ, Horsburgh MJ, Cox AG, McCleod CW, Mekhalfia A, Blackburn GM, Rice DW, Baker PJ: The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS. J Mol Biol. 2001 Oct 12;313(1):111-22. [Article]
  5. Hilgers MT, Ludwig ML: Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11169-74. Epub 2001 Sep 11. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB023215-(3-Amino-4,4-Dihyroxy-Butylsulfanylmethyl)-Tetrahydro-Furan-2,3,4-TriolexperimentalunknownDetails
DB03661L-cysteic acidexperimentalunknownDetails
DB04182(S)-2-Amino-4-[(2s,3r)-2,3,5-Trihydroxy-4-Oxo-Pentyl]Mercapto-Butyric AcidexperimentalunknownDetails
DB04422HomocysteineexperimentalunknownDetails