RNA-dependent RNA-polymerase
Details
- Name
- RNA-dependent RNA-polymerase
- Synonyms
- Not Available
- Gene Name
- NS5b
- Organism
- Hepatitis C Virus
- Amino acid sequence
>lcl|BSEQ0011720|RNA-dependent RNA-polymerase SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIR SVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS TLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIY QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS AACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPG EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIP AASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
- Number of residues
- 591
- Molecular Weight
- 65753.05
- Theoretical pI
- 9.02
- GO Classification
- Functionsnucleotide binding / RNA binding / RNA-directed RNA polymerase activityProcessesviral RNA genome replicationComponentsintegral component of membrane
- General Function
- Rna-directed rna polymerase activity
- Specific Function
- Not Available
- Pfam Domain Function
- RdRP_3 (PF00998)
- Transmembrane Regions
- 571-588
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0004719|1776 bp TCGATGTCCTACACATGGACAGGCGCCCTGATCACGCCATGCGCTGCGGAGGAATCCAAG CTGCCCATCAATGCACTGAGCAACTCTTTGCTCCGTCACCACAACATGGTCTATGCTACA ACATCTCGCAGCGCAAGCCTGCGGCAGAAGAAGGTCACCTTTGACAGACTGCAGGTCCTG GACGACCACTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCT AAACTTCTATCCGTGGAGGAAGCCTGTAAGCTGACGCCCCCACATTCGGCCAAATCTAAA TTTGGCTATGGGGCAAAGGACGTCCGGAACCTATCCAGCAAGGCCGTTAACCACATCCGC TCCGTGTGGAAGGACTTGCTGGAAGACACTGAGACACCAATTGACACCACCATCATGGCA AAAAATGAGGTTTTCTGCGTCCAACCAGAGAAGGGGGGCCGCAAGCCAGCTCGCCTTATC GTATTCCCAGATTTGGGGGTTCGTGTGTGCGAGAAAATGGCCCTTTACGATGTGGTCTCC ACCCTCCCTCAGGCCGTGATGGGCTCTTCATACGGATTCCAGTACTCTCCTGGACAGCGG GTCGAGTTCCTGGTGAATACCTGGAAATCGAAAAAATGCCCTATGGGCTTCTCATATGAC ACCCGCTGCTTTGACTCAACGGTCACTGAGAATGACATCCGTGTTGAGGAGTCAATCTAC CAATGTTGTGACTTGGCCCCCGAAGCCAGACAGGCCATAAGGTCGCTCACAGAGCGGCTT TACATCGGGGGCCCCCTGACTAATTCAAAGGGGCAGAACTGCGGCTATCGCCGGTGCCGC GCGAGCGGTGTACTGACGACCAGCTGCGGTAATACCCTCACATGTTACTTGAAGGCCTCT GCGGCCTGTCGAGCTGCGAAGCTCCAGGACTGCACGATGCTCGTGTGCGGAGACGACCTT GTCGTTATCTGTGAAAGCGCGGGGACCCAAGAGGACGCGGCGAGCCTACGAGCCTTCACG GAGGCTATGACTAGATACTCTGCCCCCCCTGGGGACCCGCCCCAACCAGAATACGACTTG GAGTTGATAACATCATGCTCCTCCAATGTGTCTGTCGCGCACGATGCATCTGGCAAAAGG GTGTACTATCTCACCCGTGACCCCACCACCCCCCTTGCGCGGGCTGCGTGGGAGACAGCT AGACACACTCCAGTCAATTCCTGGCTAGGCAACATCATCATGTATGCGCCCACCTTGTGG GCAAGGATGATCCTGATGACTCATTTCTTCTCCATCCTTCTAGCTCAGGAACAACTTGAA AAAGCCCTAGATTGTCAGATCTACGGGGCCTGTTACTCCATTGAGCCACTTGACCTACCT CAGATCATTCAACGACTCCATGGCCTTAGCGCATTTTCACTCCATAGTTACTCTCCAGGT GAGATCAATAGGGTGGCTTCATGCCTCAGGAAACTTGGGGTACCGCCCTTGCGAGTCTGG AGACATCGGGCCAGAAGTGTCCGCGCTAGGCTACTGTCCCAGGGGGGGAGGGCTGCCACT TGTGGCAAGTACCTCTTCAACTGGGCAGTAAGGACCAAGCTCAAACTCACTCCAATCCCG GCTGCGTCCCAGTTGGATTTATCCAGCTGGTTCGTTGCTGGTTACAGCGGGGGAGACATA TATCACAGCCTGTCTCGTGCCCGACCCCGCTGGTTCATGTGGTGCCTACTCCTACTTTCT GTAGGGGTAGGCATCTACCTGCTCCCCAACCGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O39930 UniProtKB Entry Name O39930_9HEPC GenBank Gene ID Z97730 - General References
- Lohmann V, Korner F, Herian U, Bartenschlager R: Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol. 1997 Nov;71(11):8416-28. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB05060 R1626 investigational unknown Details DB07199 (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID experimental unknown Details DB07200 (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID experimental unknown Details DB08934 Sofosbuvir approved yes inhibitor Details