Glutamate receptor ionotropic, delta-2
Details
- Name
- Glutamate receptor ionotropic, delta-2
- Synonyms
- GluD2
- GLURD2
- Gene Name
- GRID2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037184|Glutamate receptor ionotropic, delta-2 MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQT EKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQ RSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRG IQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAK SFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFR GNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNS KPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWN PVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSN YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA GIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSI DLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEH RTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
- Number of residues
- 1007
- Molecular Weight
- 113355.16
- Theoretical pI
- 5.95
- GO Classification
- Functionsextracellular-glutamate-gated ion channel activity / glutamate receptor activity / ionotropic glutamate receptor activity / PDZ domain binding / scaffold protein bindingProcessescellular protein localization / cerebellar granule cell differentiation / excitatory postsynaptic potential / glutamate receptor signaling pathway / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / ion transmembrane transport / ionotropic glutamate receptor signaling pathway / prepulse inhibition / regulation of neuron apoptotic process / regulation of neuron projection development / synaptic transmission, glutamatergic / transportComponentscell junction / dendrite / dendritic spine / integral component of plasma membrane / ionotropic glutamate receptor complex / plasma membrane / postsynaptic membrane / synapse
- General Function
- Scaffold protein binding
- Specific Function
- Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
- Pfam Domain Function
- Transmembrane Regions
- 567-587 636-656 831-851
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0021325|Glutamate receptor ionotropic, delta-2 (GRID2) ATGGAAGTTTTCCCCTTTCTCTTGGTTTTGTCCGTCTGGTGGTCTCGAACCTGGGACTCG GCGAATGCGGATTCGATCATTCACATCGGAGCAATTTTTGATGAATCTGCCAAAAAGGAT GATGAGGTATTTCGCACTGCGGTTGGTGACCTTAACCAGAATGAGGAGATCTTACAGACT GAGAAAATCACATTTTCAGTGACGTTTGTTGATGGCAACAACCCTTTCCAAGCAGTTCAA GAAGATATCCGTGGAATACAGGAGTTCTTGGACAAAGTCTCTCAGCAGGGAATGGATGTT GCACTTCAGAAGGTAGAAAACAACATCAATAAAATGATTACCACTCTCTTTGACACCATG AGAATAGAAGAACTGAATCGCTATCGAGACACTCTTAGGCGAGCGATCCTTGTTATGAAT CCTGCTACAGCCAAATCCTTCATTACTGAGGTTGTGGAGACTAATTTGGTTGCTTTTGAC TGTCACTGGATCATTATAAATGAGGAAATAAACGATGTGGACGTACAGGAACTTGTAAGA AGGTCAATTGGAAGGTTAACGATTATTCGGCAGACATTTCCAGTTCCCCAGAACATAAGT CAGCGGTGTTTCCGTGGCAACCATCGAATATCTTCAACATTGTGTGATCCAAAGGATCCA TTTGCTCAGAATATGGAGATTTCCAACCTTTACATATATGACACGGTGCTTCTGCTTGCT AATGCTTTTCATAAGAAGCTGGAGGACCGAAAGTGGCACAGCATGGCAAGTCTGTCATGT ATCAGAAAGAACTCAAAGCCCTGGCAGGGTGGGCGCTCCATGTTGGAGACCATCAAGAAG GGTGGAGTTAGTGGGTTGACTGGAGAGCTAGAATTTGGAGAAAATGGAGGCAATCCCAAT GTCCACTTTGAAATCCTTGGAACCAACTATGGAGAAGAGCTTGGCAGAGGTGTTCGAAAA CTTGGTTGCTGGAATCCTGTCACAGGTCTGAATGGGTCACTGACTGACAAGAAATTGGAG AATAACATGCGTGGAGTGGTTCTACGTGTAGTAACTGTTCTGGAAGAACCTTTTGTGATG GTCTCTGAAAATGTCTTGGGTAAGCCGAAGAAATACCAGGGCTTCTCCATTGATGTTTTG GATGCCTTATCTAACTACCTGGGTTTTAACTACGAAATTTACGTAGCACCGGATCACAAA TACGGAAGCCCACAAGAAGATGGGACATGGAATGGCTTGGTAGGAGAACTTGTCTTTAAG AGAGCCGACATAGGGATTTCTGCTTTAACCATCACTCCAGATCGTGAAAATGTGGTGGAC TTTACGACACGTTACATGGACTACTCAGTGGGGGTACTACTTCGAAGGGCTGAAAAGACA GTGGATATGTTTGCCTGTCTTGCACCATTTGATCTCTCTCTATGGGCTTGCATTGCTGGC ACAGTCCTTCTGGTGGGTCTACTGGTCTACCTCTTGAACTGGCTTAATCCCCCACGATTA CAAATGGGATCAATGACGTCTACTACTCTCTACAACTCCATGTGGTTTGTGTATGGATCT TTTGTACAACAAGGCGGGGAAGTCCCGTACACGACTCTGGCTACCCGAATGATGATGGGG GCTTGGTGGCTATTTGCTTTGATTGTTATCTCATCTTACACGGCAAACCTCGCTGCTTTC CTCACTATTACACGCATTGAAAGTTCCATCCAGTCTCTCCAGGACCTTTCCAAGCAAACA GAAATCCCTTATGGCACAGTCCTAGACTCTGCGGTATATGAGCATGTCCGCATGAAAGGA CTGAATCCTTTTGAGAGGGACAGCATGTATTCCCAAATGTGGCGGATGATCAACCGAAGC AATGGATCGGAGAACAATGTTCTGGAGTCCCAGGCAGGCATTCAAAAGGTAAAATATGGA AATTATGCTTTCGTATGGGATGCAGCTGTATTGGAATATGTGGCTATCAATGACCCAGAT TGTTCCTTTTACACCATTGGAAATACTGTTGCTGATCGGGGATATGGAATTGCATTACAA CATGGCAGTCCTTACCGAGATGTTTTTTCACAAAGGATCCTGGAGCTTCAGCAGAATGGT GACATGGACATCCTGAAGCACAAATGGTGGCCTAAGAATGGCCAGTGTGACCTGTACTCG TCAGTGGACACAAAGCAGAAAGGAGGCGCCCTGGACATAAAGAGCTTTGCAGGGGTCTTT TGTATCCTGGCTGCTGGAATTGTCCTCTCCTGCTTCATAGCCATGCTGGAGACGTGGTGG AACAAGAGGAAAGGCTCCCGGGTTCCATCAAAAGAGGATGACAAGGAAATTGACCTGGAG CACCTCCATAGACGTGTAAATAGCTTGTGCACAGATGACGACAGCCCCCATAAACAGTTT TCCACCTCGTCAATTGATTTGACCCCTCTGGACATTGACACTTTGCCAACACGACAAGCA CTGGAGCAAATCAGTGATTTCAGGAACACTCATATTACCACAACAACCTTTATCCCAGAG CAGATCCAGACTCTTAGCCGCACACTGTCAGCTAAAGCTGCTTCTGGTTTCACTTTTGGC AACGTGCCTGAGCACCGAACTGGCCCTTTTAGGCACAGGGCACCTAATGGGGGCTTTTTC AGGAGTCCTATAAAAACAATGTCATCTATTCCTTATCAACCAACTCCTACCCTGGGGCTC AATCTGGGTAATGATCCAGACCGAGGCACCTCCATATGA
- Chromosome Location
- 4
- Locus
- 4q22
- External Identifiers
Resource Link UniProtKB ID O43424 UniProtKB Entry Name GRID2_HUMAN GenBank Protein ID 2853315 GenBank Gene ID AF009014 GenAtlas ID GRID2 HGNC ID HGNC:4576 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details