Sulfotransferase family cytosolic 1B member 1
Details
- Name
- Sulfotransferase family cytosolic 1B member 1
- Synonyms
- 2.8.2.-
- ST1B1
- ST1B2
- Sulfotransferase 1B2
- SULT1B2
- Thyroid hormone sulfotransferase
- Gene Name
- SULT1B1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011826|Sulfotransferase family cytosolic 1B member 1 MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDM ILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFW ENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNW WKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVN YTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
- Number of residues
- 296
- Molecular Weight
- 34898.955
- Theoretical pI
- 7.07
- GO Classification
- Functionsaryl sulfotransferase activity / sulfotransferase activityProcesses3'-phosphoadenosine 5'-phosphosulfate metabolic process / cellular biogenic amine metabolic process / epithelial cell differentiation / flavonoid metabolic process / phenol-containing compound metabolic process / small molecule metabolic process / steroid metabolic process / sulfation / thyroid hormone metabolic process / xenobiotic metabolic processComponentscytosol
- General Function
- Sulfotransferase activity
- Specific Function
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.
- Pfam Domain Function
- Sulfotransfer_1 (PF00685)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011827|Sulfotransferase family cytosolic 1B member 1 (SULT1B1) ATGCTTTCCCCAAAAGATATTCTGCGAAAAGATCTGAAGTTGGTCCATGGTTATCCCATG ACCTGTGCTTTTGCAAGCAACTGGGAAAAAATTGAACAGTTCCATAGCAGACCAGATGAC ATTGTGATAGCCACTTATCCTAAATCAGGTACTACTTGGGTTAGTGAAATTATAGACATG ATTCTAAATGATGGAGATATTGAAAAATGTAAGCGAGGTTTTATTACTGAAAAAGTTCCA ATGTTGGAAATGACTCTCCCTGGATTAAGAACATCAGGTATAGAACAATTGGAGAAGAAT CCATCACCCCGGATTGTGAAAACACATCTACCGACTGATCTTCTTCCTAAATCTTTCTGG GAAAACAATTGCAAGATGATTTATCTGGCTCGTAATGCCAAGGATGTTTCAGTCTCATAT TACCATTTTGACTTAATGAATAATTTACAGCCTTTTCCTGGTACCTGGGAAGAATATCTG GAGAAATTCTTAACTGGAAAAGTGGCCTATGGTTCCTGGTTTACTCATGTTAAAAACTGG TGGAAGAAAAAGGAAGAACACCCAATACTTTTTTTGTACTATGAAGATATGAAAGAGAAT CCAAAGGAGGAAATCAAGAAGATCATTAGATTTCTAGAGAAGAACCTGAATGATGAGATC TTGGATAGGATCATCCATCACACCTCATTTGAAGTGATGAAGGACAATCCTTTGGTAAAT TATACACATCTACCAACTACAGTGATGGATCATAGCAAATCCCCTTTTATGCGTAAAGGG ACGGCTGGTGACTGGAAGAATTACTTCACCGTGGCCCAAAATGAGAAATTTGATGCTATT TATGAGACAGAAATGTCCAAAACTGCACTTCAATTCCGCACAGAGATTTAA
- Chromosome Location
- 4
- Locus
- 4q13.3
- External Identifiers
Resource Link UniProtKB ID O43704 UniProtKB Entry Name ST1B1_HUMAN GenBank Gene ID D89479 GenAtlas ID SULT1B1 HGNC ID HGNC:17845 - General References
- Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y: Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. J Biochem. 1997 Nov;122(5):1052-61. [Article]
- Wang J, Falany JL, Falany CN: Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. Mol Pharmacol. 1998 Feb;53(2):274-82. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Dombrovski L, Dong A, Bochkarev A, Plotnikov AN: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). Proteins. 2006 Sep 1;64(4):1091-4. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01812 Adenosine 3',5'-diphosphate experimental unknown Details DB14635 Curcumin sulfate experimental unknown substrate Details DB09100 Thyroid, porcine approved unknown substrate Details DB00714 Apomorphine approved, investigational unknown substrate Details DB00871 Terbutaline approved unknown substrate Details DB00960 Pindolol approved, investigational unknown substrate Details DB00968 Methyldopa approved no substrate Details DB12471 Ibrexafungerp approved, investigational unknown substrate Details DB00867 Ritodrine approved, investigational no substrate Details DB12243 Edaravone approved, investigational no substrate Details