85/88 kDa calcium-independent phospholipase A2
Details
- Name
- 85/88 kDa calcium-independent phospholipase A2
- Synonyms
- 3.1.1.4
- CaI-PLA2
- Group VI phospholipase A2
- GVI PLA2
- Intracellular membrane-associated calcium-independent phospholipase A2 beta
- iPLA2-beta
- Patatin-like phospholipase domain-containing protein 9
- PLPLA9
- PNPLA9
- Gene Name
- PLA2G6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002143|85/88 kDa calcium-independent phospholipase A2 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN ALWETEVYIYEHREEFQKLIQLLLSP
- Number of residues
- 806
- Molecular Weight
- 89902.295
- Theoretical pI
- 7.28
- GO Classification
- Functionsphospholipase A2 activityProcessesantibacterial humoral response / cardiolipin acyl-chain remodeling / cardiolipin biosynthetic process / chemotaxis / Fc-gamma receptor signaling pathway involved in phagocytosis / glycerophospholipid biosynthetic process / innate immune response / lipid catabolic process / phosphatidylcholine acyl-chain remodeling / phosphatidylethanolamine acyl-chain remodeling / phospholipid metabolic process / small molecule metabolic processComponentscytoplasm / cytosol / extracellular space / membrane / microtubule organizing center
- General Function
- Phospholipase a2 activity
- Specific Function
- Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010755|85/88 kDa calcium-independent phospholipase A2 (PLA2G6) ATGCAGTTCTTTGGCCGCCTGGTCAATACCTTCAGTGGCGTCACCAACTTGTTCTCTAAC CCATTCCGGGTGAAGGAGGTGGCTGTGGCCGACTACACCTCGAGTGACCGAGTTCGGGAG GAAGGGCAGCTGATTCTGTTCCAGAACACTCCCAACCGCACCTGGGACTGCGTCCTGGTC AACCCCAGGAACTCACAGAGTGGATTCCGACTCTTCCAGCTGGAGTTGGAGGCTGACGCC CTAGTGAATTTCCATCAGTATTCTTCCCAGCTGCTACCCTTCTATGAGAGCTCCCCTCAG GTCCTGCACACTGAGGTCCTGCAGCACCTGACCGACCTCATCCGTAACCACCCCAGCTGG TCAGTGGCCCACCTGGCTGTGGAGCTAGGGATCCGCGAGTGCTTCCATCACAGCCGTATC ATCAGCTGTGCCAATTGCGCGGAGAACGAGGAGGGCTGCACACCCCTGCACCTGGCCTGC CGCAAGGGTGATGGGGAGATCCTGGTGGAGCTGGTGCAGTACTGCCACACTCAGATGGAT GTCACCGACTACAAGGGAGAGACCGTCTTCCATTATGCTGTCCAGGGTGACAATTCTCAG GTGCTGCAGCTCCTTGGAAGGAACGCAGTGGCTGGCCTGAACCAGGTGAATAACCAAGGG CTGACCCCGCTGCACCTGGCCTGCCAGCTGGGGAAGCAGGAGATGGTCCGCGTGCTGCTG CTGTGCAATGCTCGGTGCAACATCATGGGCCCCAACGGCTACCCCATCCACTCGGCCATG AAGTTCTCTCAGAAGGGGTGTGCGGAGATGATCATCAGCATGGACAGCAGCCAGATCCAC AGCAAAGACCCCCGTTACGGAGCCAGCCCCCTCCACTGGGCCAAGAACGCAGAGATGGCC CGCATGCTGCTGAAACGGGGCTGCAACGTGAACAGCACCAGCTCCGCGGGGAACACGGCC CTGCACGTGGCGGTGATGCGCAACCGCTTCGACTGTGCCATAGTGCTGCTGACCCACGGG GCCAACGCGGATGCCCGCGGAGAGCACGGCAACACCCCGCTGCACCTGGCCATGTCGAAA GACAACGTGGAGATGATCAAGGCCCTCATCGTGTTCGGAGCAGAAGTGGACACCCCGAAT GACTTTGGGGAGACTCCTACATTCCTAGCCTCCAAAATCGGCAGACAACTACAGGATCTC ATGCACATCTCACGGGCCCGGAAGCCAGCGTTCATCCTGGGCTCCATGAGGGACGAGAAG CGGACCCACGACCACCTGCTGTGCCTGGATGGAGGAGGAGTGAAAGGCCTCATCATCATC CAGCTCCTCATCGCCATCGAGAAGGCCTCGGGTGTGGCCACCAAGGACCTGTTTGACTGG GTGGCGGGCACCAGCACTGGAGGCATCCTGGCCCTGGCCATTCTGCACAGTAAGTCCATG GCCTACATGCGCGGCATGTACTTTCGCATGAAGGATGAGGTGTTCCGGGGCTCCAGGCCC TACGAGTCGGGGCCCCTGGAGGAGTTCCTGAAGCGGGAGTTTGGGGAGCACACCAAGATG ACGGACGTCAGGAAACCCAAGGTGATGCTGACAGGGACACTGTCTGACCGGCAGCCGGCT GAACTCCACCTCTTCCGGAACTACGATGCTCCAGAAACTGTCCGGGAGCCTCGTTTCAAC CAGAACGTTAACCTCAGGCCTCCAGCTCAGCCCTCAGACCAGCTGGTGTGGCGGGCGGCC CGAAGCAGCGGGGCAGCTCCTACTTACTTCCGACCCAATGGGCGCTTCCTGGACGGTGGG CTGCTGGCCAACAACCCCACGCTGGATGCCATGACCGAGATCCATGAGTACAATCAGGAC CTGATCCGCAAGGGTCAGGCCAACAAGGTGAAGAAACTCTCCATCGTTGTCTCCCTGGGG ACAGGGAGGTCCCCACAAGTGCCTGTGACCTGTGTGGATGTCTTCCGTCCCAGCAACCCC TGGGAGCTGGCCAAGACTGTTTTTGGGGCCAAGGAACTGGGCAAGATGGTGGTGGACTGT TGCACGGATCCAGACGGGCGGGCTGTGGACCGGGCACGGGCCTGGTGCGAGATGGTCGGC ATCCAGTACTTCAGATTGAACCCCCAGCTGGGGACGGACATCATGCTGGATGAGGTCAGT GACACAGTGCTGGTCAACGCCCTCTGGGAGACCGAGGTCTACATCTATGAGCACCGCGAG GAGTTCCAGAAGCTCATCCAGCTGCTGCTCTCACCCTGA
- Chromosome Location
- 22
- Locus
- 22q13.1
- External Identifiers
Resource Link UniProtKB ID O60733 UniProtKB Entry Name PLPL9_HUMAN GenBank Protein ID 3142700 GenBank Gene ID AF064594 GenAtlas ID PLA2G6 HGNC ID HGNC:9039 - General References
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