Transporter
Details
- Name
- Transporter
- Synonyms
- Not Available
- Gene Name
- snf
- Organism
- Aquifex aeolicus (strain VF5)
- Amino acid sequence
>lcl|BSEQ0012739|Transporter MEVKREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMW IEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAI KFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINV SILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKD PGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIP AAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIM QPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTEL IIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETH WTVWITRFYIIGLFLFLTFLVFLAERRRNHESA
- Number of residues
- 513
- Molecular Weight
- 57407.51
- Theoretical pI
- 9.17
- GO Classification
- FunctionsneurotransmitterComponentsintegral component of membrane
- General Function
- Neurotransmitter:sodium symporter activity
- Specific Function
- Not Available
- Pfam Domain Function
- SNF (PF00209)
- Transmembrane Regions
- 12-29 41-61 92-111 166-185 197-215 243-268 289-314 342-367 379-399 405-427 447-469 481-504
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012740|Transporter (snf) ATGGAAGTTAAAAGGGAACACTGGGCGACGCGACTCGGTTTAATCCTCGCGATGGCGGGG AACGCGGTAGGACTTGGTAATTTCCTCAGATTTCCCGTTCAAGCTGCGGAAAACGGTGGC GGGGCTTTCATGATCCCATACATAATAGCCTTCCTCCTCGTGGGTATTCCTCTTATGTGG ATAGAGTGGGCTATGGGAAGATACGGGGGAGCTCAGGGACACGGAACCACACCAGCTATT TTTTACCTCCTCTGGAGAAACAGGTTTGCTAAAATTCTTGGAGTTTTCGGACTCTGGATA CCTCTGGTGGTAGCCATATACTACGTTTACATAGAGAGCTGGACACTAGGTTTTGCGATA AAGTTTTTGGTAGGGTTAGTTCCAGAACCTCCGCCAAACGCCACGGATCCCGATTCCATT CTCAGACCCTTTAAAGAATTTCTGTACTCCTACATCGGAGTTCCTAAAGGAGATGAGCCG ATTTTGAAACCTTCACTTTTTGCGTACATAGTCTTTTTAATAACTATGTTCATTAACGTT TCCATTCTCATAAGGGGTATATCCAAGGGTATAGAGAGGTTTGCAAAAATAGCTATGCCC ACGCTCTTTATCCTCGCGGTTTTTCTGGTCATCAGGGTCTTTTTACTGGAAACCCCCAAC GGCACCGCGGCGGACGGACTTAACTTCCTTTGGACTCCCGACTTTGAGAAATTAAAGGAC CCGGGCGTCTGGATAGCGGCTGTAGGACAAATATTCTTCACCCTGAGTCTTGGTTTTGGA GCTATAATCACTTACGCCTCTTACGTGAGAAAGGATCAGGACATTGTCCTCAGCGGACTT ACGGCGGCGACGTTGAACGAAAAGGCTGAGGTAATACTGGGTGGTTCTATTTCCATACCC GCTGCGGTTGCTTTCTTCGGAGTTGCAAATGCGGTTGCGATTGCAAAGGCGGGAGCCTTT AACCTCGGTTTTATAACCCTACCCGCCATATTCTCCCAAACGGCCGGAGGAACCTTTTTA GGATTTCTGTGGTTCTTCCTCCTCTTCTTCGCAGGACTCACTTCTTCAATAGCTATAATG CAACCGATGATAGCCTTCTTAGAGGACGAACTAAAGCTTAGCAGAAAACACGCTGTTCTC TGGACCGCGGCTATAGTTTTCTTCAGTGCACACCTTGTGATGTTCTTAAACAAGTCCCTT GACGAGATGGACTTCTGGGCGGGAACGATAGGGGTTGTTTTCTTTGGTCTCACAGAGCTC ATAATCTTCTTCTGGATTTTCGGAGCGGATAAAGCTTGGGAGGAGATAAACAGGGGCGGA ATTATTAAAGTTCCCAGAATTTATTATTACGTAATGAGGTATATAACCCCCGCTTTCCTC GCGGTGCTCCTCGTTGTGTGGGCACGGGAGTACATACCGAAGATCATGGAAGAGACCCAC TGGACCGTGTGGATAACACGCTTTTACATAATAGGGCTTTTCCTCTTCCTCACTTTCCTC GTTTTCTTAGCTGAACGGAGAAGAAACCATGAGAGTGCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O67854 UniProtKB Entry Name O67854_AQUAE GenBank Protein ID 2982776 GenBank Gene ID AE000657 - General References
- Deckert G, Warren PV, Gaasterland T, Young WG, Lenox AL, Graham DE, Overbeek R, Snead MA, Keller M, Aujay M, Huber R, Feldman RA, Short JM, Olsen GJ, Swanson RV: The complete genome of the hyperthermophilic bacterium Aquifex aeolicus. Nature. 1998 Mar 26;392(6674):353-8. [Article]
- Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E: Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature. 2005 Sep 8;437(7056):215-23. Epub 2005 Jul 24. [Article]
- Singh SK, Yamashita A, Gouaux E: Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature. 2007 Aug 23;448(7156):952-6. Epub 2007 Aug 8. [Article]
- Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN: LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science. 2007 Sep 7;317(5843):1390-3. Epub 2007 Aug 9. [Article]
- Singh SK, Piscitelli CL, Yamashita A, Gouaux E: A competitive inhibitor traps LeuT in an open-to-out conformation. Science. 2008 Dec 12;322(5908):1655-61. doi: 10.1126/science.1166777. [Article]
- Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN: Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009 Jun;16(6):652-7. doi: 10.1038/nsmb.1602. Epub 2009 May 10. [Article]
- Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA: Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8. doi: 10.1073/pnas.0811322106. Epub 2009 Mar 23. [Article]
- Kroncke BM, Horanyi PS, Columbus L: Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites. Biochemistry. 2010 Nov 30;49(47):10045-60. doi: 10.1021/bi101148w. Epub 2010 Nov 8. [Article]
- Piscitelli CL, Gouaux E: Insights into transport mechanism from LeuT engineered to transport tryptophan. EMBO J. 2012 Jan 4;31(1):228-35. doi: 10.1038/emboj.2011.353. Epub 2011 Sep 27. [Article]
- Wang H, Gouaux E: Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep. 2012 Sep;13(9):861-6. doi: 10.1038/embor.2012.110. Epub 2012 Jul 27. [Article]
- Wang H, Elferich J, Gouaux E: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol. 2012 Jan 15;19(2):212-9. doi: 10.1038/nsmb.2215. [Article]
- Krishnamurthy H, Gouaux E: X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature. 2012 Jan 9;481(7382):469-74. doi: 10.1038/nature10737. [Article]
- Wang H, Goehring A, Wang KH, Penmatsa A, Ressler R, Gouaux E: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature. 2013 Nov 7;503(7474):141-5. doi: 10.1038/nature12648. Epub 2013 Oct 13. [Article]